Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.44 |
| ▸ | AGT | P01019 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 2/20 | 0.35 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839523 | 0.86 | CD274 (0.51) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL9541811 | 0.85 | AGTR1 (0.50) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL489527 | 0.84 | AGTR1 (0.49) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL3950208 | 0.83 | AGTR1 (0.49) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL8532808 | 0.83 | AGTR1 (0.51) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL3948155 | 0.81 | LTB4R2 (0.57) | AGTR1AGTR2AGTLTB4R2GAA | |
| SCHEMBL9413763 | 0.78 | AGTR1 (0.45) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL839254 | 0.78 | CD274 (0.47) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL9093218 | 0.78 | AGTR1 (0.48) | AGTR1AGTR2AGTPDCD1CD274 | |
| SCHEMBL13679199 | 0.77 | AGTR1 (0.47) | AGTR1AGTR2AGTLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132187-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008097459-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-08-14 | — | — | WO | disclosed |