Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PHGDH | O43175 | 3/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963189 | 0.84 | MAPK8 (0.36) | MAPK8MAPK9MAPK10MCHR1PIM1 | |
| SCHEMBL962752 | 0.84 | PTGDR2 (0.31) | PHGDHPPARGPPARAPTGDR2 | |
| SCHEMBL964535 | 0.82 | OXER1 (0.33) | PLA2G4APTGDR2 | |
| SCHEMBL968367 | 0.82 | TP53 (0.35) | MAPK8PLA2G4A | |
| SCHEMBL965461 | 0.82 | PTGDR2 (0.32) | MAPK8MAPK9MAPK10PHGDHPTGDR2 | |
| SCHEMBL4554828 | 0.81 | AGTR2 (0.38) | PLA2G4APDE2APHGDHPPARG | |
| SCHEMBL963060 | 0.81 | TP53 (0.34) | PLA2G4APHGDHPTGDR2 | |
| SCHEMBL4554130 | 0.81 | MAPK8 (0.40) | MAPK8MAPK9MAPK10PLA2G4AMCHR1 | |
| SCHEMBL4553883 | 0.80 | SMN1; SMN2 (0.33) | MAPK8MAPK9MAPK10PLA2G4APHGDH | |
| SCHEMBL4570493 | 0.80 | PHGDH (0.36) | MAPK8MAPK9MAPK10PLA2G4APHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |