Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 4/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PHGDH | O43175 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553883 | 0.91 | SMN1; SMN2 (0.33) | MCL1PLA2G4AGALR3CYP1A2CYP3A4 | |
| SCHEMBL4554740 | 0.91 | AGTR2 (0.37) | AGTR2AGTR1MCL1PLA2G4APPARG | |
| SCHEMBL4555122 | 0.88 | MAPK8 (0.37) | MCL1PLA2G4AGALR3CYP1A2CYP3A4 | |
| SCHEMBL968367 | 0.87 | TP53 (0.35) | MCL1PLA2G4A | |
| SCHEMBL4553444 | 0.84 | SMN1; SMN2 (0.44) | MCL1PLA2G4AGALR3CYP1A2CYP3A4 | |
| SCHEMBL4553762 | 0.84 | AGTR2 (0.37) | AGTR2AGTR1MCL1PPARG | |
| SCHEMBL4554652 | 0.84 | GABRA1 (0.36) | AGTR2MCL1PLA2G4AGALR3CYP1A2 | |
| SCHEMBL4570493 | 0.84 | PHGDH (0.36) | MCL1PLA2G4APHGDH | |
| SCHEMBL963060 | 0.83 | TP53 (0.34) | MCL1PLA2G4ASMN1; SMN2PHGDH | |
| SCHEMBL4554438 | 0.83 | MAPK8 (0.35) | AGTR2MCL1PLA2G4AGALR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |