Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.46 |
| ▸ | CA1 | P00915 | 12/20 | 0.46 |
| ▸ | CA12 | O43570 | 10/20 | 0.46 |
| ▸ | CA9 | Q16790 | 8/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | IL1RN | P18510 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743022 | 0.89 | CA2 (0.49) | CA2CA1CA12CA9CA14 | |
| SCHEMBL3729753 | 0.83 | CA2 (0.56) | CA2CA1CA12CA9PTGS2 | |
| SCHEMBL4555164 | 0.75 | CA2 (0.54) | CA2CA1CA12CA9CA7 | |
| SCHEMBL4553904 | 0.74 | CA2 (0.48) | CA2CA1CA12CA9CA7 | |
| SCHEMBL31675059 | 0.72 | IL1RN (0.53) | PTGS2IL1RNERAP2PTPN2PTPN1 | |
| SCHEMBL3743147 | 0.72 | CA2 (0.49) | CA2CA1CA12CA9PTGS2 | |
| SCHEMBL31675092 | 0.68 | PTGS2 (0.49) | CA2CA1CA12CA9PTGS2 | |
| SCHEMBL31675086 | 0.67 | IL1RN (0.47) | PTGS2IL1RNERAP2PTPN2PTPN1 | |
| SCHEMBL13012614 | 0.67 | CA2 (0.62) | CA2CA1CA12CA9PTGS2 | |
| SCHEMBL3736212 | 0.66 | CA2 (0.48) | CA2CA1CA12CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129666-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | Siemens Medical Solutions USA, Inc. (US) | 2009-12-09 | — | — | EP | claimed |
| WO-2008124703-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2008-10-16 | — | — | WO | claimed |
| EP-2129666-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | Siemens Medical Solutions USA, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008124703-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2008-10-16 | — | — | WO | disclosed |