Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 17/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16964393 | 0.86 | FOLH1 (0.53) | FOLH1CYP19A1CYP1A1 | |
| SCHEMBL5804564 | 0.85 | FOLH1 (0.44) | FOLH1CYP19A1CYP1A1 | |
| SCHEMBL6616572 | 0.82 | FOLH1 (0.42) | FOLH1CYP19A1CYP1A1AURKARPS6KB1 | |
| SCHEMBL2754373 | 0.79 | LMNA (0.38) | FOLH1CYP19A1 | |
| SCHEMBL27349224 | 0.79 | FOLH1 (0.47) | FOLH1CYP19A1CYP1A1AURKARPS6KB1 | |
| SCHEMBL4485559 | 0.79 | CYP19A1 (0.47) | FOLH1CYP19A1CYP1A1AURKARPS6KB1 | |
| SCHEMBL612982 | 0.71 | FOLH1 (0.55) | FOLH1CYP19A1CYP1A1 | |
| SCHEMBL6395050 | 0.71 | FOLH1 (0.55) | FOLH1CYP19A1CYP1A1 | |
| SCHEMBL16965550 | 0.71 | CYP19A1 (0.41) | FOLH1CYP19A1CYP1A1 | |
| SCHEMBL29201284 | 0.70 | CYP19A1 (0.48) | FOLH1CYP19A1CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129666-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | Siemens Medical Solutions USA, Inc. (US) | 2009-12-09 | — | — | EP | claimed |
| WO-2008124703-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2008-10-16 | — | — | WO | claimed |
| EP-2900665-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2129666-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | Siemens Medical Solutions USA, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008124703-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2008-10-16 | — | — | WO | disclosed |