Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554946 | 0.89 | GPR119 (0.41) | GPR119KCNH2RIPK1CHRNB2CHRNB4 | |
| SCHEMBL3617657 | 0.78 | GPR119 (0.58) | GPR119KCNH2RIPK1CHEK1KDR | |
| SCHEMBL3485814 | 0.74 | GPR119 (0.60) | GPR119KCNH2RIPK1CHEK1KDR | |
| SCHEMBL3616496 | 0.71 | GPR119 (0.53) | GPR119KCNH2RIPK1CHEK1CHEK2 | |
| SCHEMBL3626185 | 0.69 | GPR119 (0.54) | GPR119KCNH2RIPK1CHEK1KDR | |
| SCHEMBL4555154 | 0.68 | GPR119 (0.39) | GPR119RIPK1CHEK1CHEK2 | |
| SCHEMBL3430648 | 0.68 | AR (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL27226303 | 0.67 | KDR (0.53) | GPR119RIPK1CHEK1KDR | |
| SCHEMBL4435835 | 0.65 | HRH4 (0.33) | GPR119CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL4434104 | 0.64 | CYP1A2 (0.39) | GPR119CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | claimed |
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |