SCHEMBL4435835

SCHEMBL4435835

CC(C)(C)[C@H]1CC(C2CCNCC2)CCN1c1cc(Cl)ncn1

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.33
MMP2 P08253 1/20 0.33
ADAMTS5 Q9UNA0 1/20 0.33
CHRNB2 P17787 6/20 0.32
CHRNB4 P30926 6/20 0.32
CHRNA3 P32297 6/20 0.32
CHRNA4 P43681 6/20 0.32
GPR119 Q8TDV5 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
L3MBTL3 Q96JM7 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4434104 0.80 CYP1A2 (0.39) HRH4CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL10276684 0.73 HCRTR1 (0.41) HRH4ALDH1A1
SCHEMBL4937062 0.68 BPTF (0.51) HRH4CHRNB2CHRNA4ALDH1A1CYP1A2
SCHEMBL3652745 0.67 GPR119 (0.35) GPR119
Hydrochloric Acid SCHEMBL4818046 0.66 BPTF (0.50) HRH4CHRNB2CHRNA4ALDH1A1CYP1A2
SCHEMBL4555485 0.66 GPR119 (0.39) GPR119ALDH1A1
SCHEMBL20898548 0.66 LRRK2 (0.45) MMP2ADAMTS5
SCHEMBL4431799 0.66 GPR119 (0.43) GPR119ALDH1A1L3MBTL3L3MBTL1
SCHEMBL17884822 0.65 MMP2 (0.42) MMP2ADAMTS5
SCHEMBL4554925 0.65 GPR119 (0.39) CHRNB2CHRNB4CHRNA3CHRNA4GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2121661-A1 BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT Merck & Co., Inc. (US) 2009-11-25 EP disclosed
WO-2008085316-A1 BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT MERCK & CO., INC. (US) 2008-07-17 WO disclosed