Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PARL | Q9H300 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1156431 | 0.81 | HTR6 (0.43) | HTR6ALDH1A1ACHEKDM4EGAA | |
| SCHEMBL1580856 | 0.77 | HTR6 (0.40) | HTR6ALDH1A1ACHEEPHX2 | |
| Hydrochloric Acid SCHEMBL1156400 | 0.76 | HTR6 (0.39) | HTR6ALDH1A1ACHEKDM4EEPHX2 | |
| SCHEMBL1156305 | 0.74 | MAPK1 (0.47) | ALDH1A1HTTNPC1 | |
| SCHEMBL1156715 | 0.73 | ACHE (0.41) | HTR6ALDH1A1ACHEKDM4ELMNA | |
| SCHEMBL1799962 | 0.70 | BRD4 (0.54) | HTR6ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL1580453 | 0.69 | HTR6 (0.41) | HTR6ALDH1A1ACHEKDM4E | |
| Hydrochloric Acid SCHEMBL1156630 | 0.69 | HTR6 (0.41) | HTR6ALDH1A1ACHEKDM4E | |
| SCHEMBL1156354 | 0.69 | KMT2A (0.49) | ALDH1A1KDM4EGAALMNATSHR | |
| SCHEMBL29065523 | 0.67 | HTR6 (0.38) | HTR6ALDH1A1KDM4EPARL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125801-A1 | THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | Eisai R&D Management Co., Ltd. (JP) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008095943-A1 | THE USE OF 7-AZAINDOLES IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |