Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555465 | 0.87 | LMNA (0.44) | LMNAMAPK1GLANOD2SMN1; SMN2 | |
| SCHEMBL4553190 | 0.85 | LMNA (0.46) | LMNAMAPK1GLANOD2SMN1; SMN2 | |
| SCHEMBL4554891 | 0.85 | FFAR1 (0.44) | — | |
| SCHEMBL4554910 | 0.84 | HPGD (0.35) | LMNASMN1; SMN2ALDH1A1KMT2AHPGD | |
| SCHEMBL3738041 | 0.80 | LMNA (0.50) | LMNAMAPK1GLANOD2SMN1; SMN2 | |
| SCHEMBL3727140 | 0.79 | LMNA (0.49) | LMNAMAPK1GLANOD2SMN1; SMN2 | |
| SCHEMBL3727808 | 0.79 | LMNA (0.48) | LMNAMAPK1GLANOD2SMN1; SMN2 | |
| SCHEMBL3728273 | 0.78 | LMNA (0.51) | LMNAMAPK1GLANOD2SMN1; SMN2 | |
| SCHEMBL3729035 | 0.77 | LMNA (0.48) | LMNAMAPK1GLANOD2SMN1; SMN2 | |
| SCHEMBL3729966 | 0.77 | LMNA (0.50) | LMNAMAPK1GLANOD2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125799-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008104524-A1 | THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-04 | — | — | WO | disclosed |