Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAC1 | P63000 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2819888 | 0.91 | FLT3 (0.54) | FLT3NTRK1NTRK2CDK2KDM4E | |
| SCHEMBL2816744 | 0.90 | ROCK1 (0.49) | FLT3NTRK1CDK2NPC1ALDH1A1 | |
| SCHEMBL27796823 | 0.89 | NTRK1 (0.62) | FLT3NTRK1NTRK2CDK2KDM4E | |
| SCHEMBL2815480 | 0.88 | NTRK1 (0.53) | FLT3NTRK1NTRK2CDK2KDM4E | |
| SCHEMBL2818030 | 0.88 | NTRK1 (0.52) | FLT3NTRK1NTRK2CDK2KDM4E | |
| SCHEMBL4555729 | 0.86 | NTRK1 (0.52) | FLT3NTRK1NTRK2CDK2RAC1 | |
| SCHEMBL2818006 | 0.83 | MEN1 (0.53) | NPC1L3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL2816819 | 0.83 | MEN1 (0.63) | KDM4ENPC1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4555727 | 0.82 | FLT3 (0.52) | FLT3NTRK1NTRK2CDK2KDM4E | |
| SCHEMBL4556336 | 0.81 | NPC1 (0.58) | KDM4ENPC1ALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134676-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | Addex Pharma SA (CH) | 2009-12-23 | — | — | EP | claimed |
| WO-2008117175-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | ADDEX PHARMA SA (CH) | 2008-10-02 | — | — | WO | claimed |
| EP-2134676-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | Addex Pharma SA (CH) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008117175-A2 | NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | ADDEX PHARMA SA (CH) | 2008-10-02 | — | — | WO | disclosed |