Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28737083 | 0.84 | GPR84 (0.60) | ACE2GPR84FFAR1FFAR4CA1 | |
| Bicarbonate SCHEMBL154438 | 0.84 | GPR84 (0.60) | ACE2GPR84FFAR1FFAR4CA1 | |
| Bicarbonate SCHEMBL4555786 | 0.84 | TSHR (0.38) | ACE2MAPTSLC1A2SLC1A1 | |
| Bicarbonate SCHEMBL28559081 | 0.82 | GPR84 (0.64) | ACE2GPR84FFAR1FFAR4MAPT | |
| SCHEMBL4555763 | 0.82 | ACE2 (0.40) | ACE2GPR84FFAR1FFAR4CA1 | |
| Lactic Acid SCHEMBL10794173 | 0.78 | GPR84 (0.59) | ACE2GPR84FFAR1FFAR4CA1 | |
| SCHEMBL4651838 | 0.78 | GPR84 (0.59) | ACE2GPR84FFAR1FFAR4CA1 | |
| SCHEMBL15648675 | 0.78 | GPR84 (0.59) | ACE2GPR84FFAR1FFAR4CA1 | |
| Bicarbonate SCHEMBL18274643 | 0.78 | ACE2 (0.64) | ACE2GPR84FFAR1FFAR4CA1 | |
| Acetic Acid SCHEMBL15793456 | 0.78 | GPR84 (0.58) | ACE2GPR84FFAR1FFAR4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312444-A1 | CAST MOLDED ARTICLE MADE OF POLYURETHANE POROUS SUBSTANCE AND METHOD FOR PRODUCING THE SAME | TOYO POLYMER CO., LTD. (JP) | 2009-12-17 | — | — | US | disclosed |