Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37152 | 0.89 | — | — | |
| Methacrylic Acid SCHEMBL1899984 | 0.84 | TSHR (0.32) | TSHRPTPN1 | |
| Adipic Acid SCHEMBL2947225 | 0.84 | AKR1B1 (0.48) | TSHRMAPTPTPN1 | |
| Acrylic Acid SCHEMBL11105429 | 0.84 | LMNA (0.42) | TSHRPTPN1 | |
| Acrylic Acid SCHEMBL7740689 | 0.84 | LMNA (0.42) | TSHRPTPN1 | |
| Bicarbonate SCHEMBL4555762 | 0.84 | ACE2 (0.46) | SLC1A2SLC1A1MAPTACE2 | |
| SCHEMBL29138421 | 0.81 | TSHR (0.40) | TSHRPTPN1 | |
| Terephthalic Acid SCHEMBL28926617 | 0.81 | MAPT (0.57) | TSHRTP53MAPT | |
| SCHEMBL27587381 | 0.81 | PTPN1 (0.33) | PTPN1 | |
| Bicarbonate SCHEMBL9490653 | 0.80 | FFAR3 (0.41) | TSHRTP53MAPTFFAR3ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312444-A1 | CAST MOLDED ARTICLE MADE OF POLYURETHANE POROUS SUBSTANCE AND METHOD FOR PRODUCING THE SAME | TOYO POLYMER CO., LTD. (JP) | 2009-12-17 | — | — | US | disclosed |