Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.97 |
| ▸ | MEN1 | O00255 | 3/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | IL1RN | P18510 | 1/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31684032 | 1.00 | ALDH1A1 (0.97) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL15010078 | 0.98 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL10726996 | 0.91 | ALDH1A1 (0.86) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL27974975 | 0.85 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL848429 | 0.83 | KMT2A (0.73) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL654409 | 0.83 | MEN1 (0.73) | ALDH1A1MEN1KMT2ATHRBHTT | |
| SCHEMBL12674581 | 0.83 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL12674480 | 0.81 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL18948489 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL2960456 | 0.80 | MEN1 (0.68) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134714-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | Biovitrum AB (publ) (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008110598-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | BIOVITRUM AB (PUBL) (SE) | 2008-09-18 | — | — | WO | disclosed |