Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diflorasone Diacetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 9/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | AR | P10275 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.65 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diflorasone Diacetate SCHEMBL10599667 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL14410916 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL7101720 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL14339606 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL11020196 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL11020199 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL11430576 | 0.94 | NR3C1 (0.88) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL11423833 | 0.93 | NR3C1 (0.87) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL11600201 | 0.92 | NR3C1 (0.85) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL3164036 | 0.92 | NR3C1 (0.85) | HIF1APGRNR3C1ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 21810 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139030-A1 | CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION | SHATTUCK LABS INC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137657-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137656-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | claimed |
| EP-4744657-A1 | THERAPEUTIC AGENT FOR HUMAN GRAFT VERSUS HOST DISEASE AND COMBINATION THEREOF | National University Corporation Okayama University (JP) | 2026-05-20 | — | — | EP | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| US-20260103492-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2026-04-16 | — | — | US | claimed |
| US-20260027255-A1 | Cross-Linked Telechelic Polymer Compositions, Methods of Preparation Thereof, and Methods of Using Same | BETTY YU SKIN TECH ADVISORS LLC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4656202-A1 | TREATMENT OF ATOPIC DERMATITIS WITH POLYETHYLENE GLYCOL-MODIFIED INTERLEUKIN 2, GLUCOCORTICOID AND HYALURONIC ACID | Xie, Yanhui (CN) | 2025-12-03 | — | — | EP | claimed |
| US-20250319104-A1 | MOISTURIZING CREAM FOR RADIATION DERMATITIS | PERRY ARTHUR W (US) | 2025-10-16 | — | — | US | claimed |
| US-20250302917-A1 | METHODS OF REDUCING THE SIGNS OR SYMPTOMS OF DERMAL DISORDERS WITH TOPICALLY APPLIED SILK FIBROIN | COCOON BIOTECH INC (US) | 2025-10-02 | — | — | US | claimed |
| US-4844902-A | Topically applicable formulations of gyrase inhibitors in combination with corticosteroids | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-04 | — | — | US | claimed |
| US-4840772-A | KIT WITH CONTAINERS OF AGENT TO REDUCE INTRAOCULAR PRESSURE AND ANTIINFLAMMATORY STEROID OR BETA-BLOCKER | SCHERING CORPORATION (US) | 1989-06-20 | — | — | US | claimed |
| US-4783444-A | SUBSTITUTED DIPEPTIDES | SCHERING CORPORATION (US) | 1988-11-08 | — | — | US | claimed |
| EP-0068553-B1 | TOPICAL ANTIMICROBIAL ANTI-INFLAMMATORY COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1985-11-21 | — | — | EP | claimed |
| US-4427670-A | CONTAINING CORTICOSTEROID, PHOSPHATIDE, AND BUTYLHYDROXYANISOLE, OR BUTYLHYDROXYTOLUENE | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1984-01-24 | — | — | US | claimed |
| EP-0068553-A1 | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1983-01-05 | — | — | EP | claimed |
| US-4343798-A | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1982-08-10 | — | — | US | claimed |
| US-4083974-A | Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether | THE UPJOHN COMPANY (US) | 1978-04-11 | — | — | US | claimed |
| US-4041055-A | SULFENYLATION, MICHAEL ADDITION, REACTION WITH THIOPHILE, HYDROLYSIS | THE UPJOHN COMPANY (US) | 1977-08-09 | — | — | US | claimed |
| US-3980778-A | Anti-inflammatory steroid | THE UPJOHN COMPANY (US) | 1976-09-14 | — | — | US | claimed |