Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diflorasone Diacetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 9/20 | 1.00 |
| ▸ | PGR | P06401 | 7/20 | 1.00 |
| ▸ | AR | P10275 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.65 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diflorasone Diacetate SCHEMBL10599667 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL14410916 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL4556 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL14339606 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL11020196 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| Diflorasone Diacetate SCHEMBL11020199 | 1.00 | HIF1A (1.00) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL11430576 | 0.94 | NR3C1 (0.88) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL11423833 | 0.93 | NR3C1 (0.87) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL11600201 | 0.92 | NR3C1 (0.85) | HIF1APGRNR3C1ARCYP3A4 | |
| SCHEMBL3164036 | 0.92 | NR3C1 (0.85) | HIF1APGRNR3C1ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4041055-A | SULFENYLATION, MICHAEL ADDITION, REACTION WITH THIOPHILE, HYDROLYSIS | THE UPJOHN COMPANY (US) | 1977-08-09 | — | — | US | claimed |
| US-3980778-A | Anti-inflammatory steroid | THE UPJOHN COMPANY (US) | 1976-09-14 | — | — | US | claimed |
| US-20030130248-A1 | Topical anti-inflammatory compositions | AVENTIS PHARMACEUTICALS HOLDINGS INC. | 2003-07-10 | — | — | US | disclosed |
| EP-0402963-A2 | 17-Alpha ethynyl steroids | THE UPJOHN COMPANY (US) | 1990-12-19 | — | — | EP | disclosed |
| US-4614621-A | Ethynylation of 16-methylene-17-keto steroids | THE UPJOHN COMPANY (US) | 1986-09-30 | — | — | US | disclosed |
| US-4567001-A | 16-Methylene-17α-hydroxy-progesterones | THE UPJOHN COMPANY (US) | 1986-01-28 | — | — | US | disclosed |
| US-4526720-A | Process to prepare stabilized monolithium acetylide | THE UPJOHN COMPANY (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0104054-A2 | 16-methylene-steroids and their preparation | THE UPJOHN COMPANY (US) | 1984-03-28 | — | — | EP | disclosed |
| US-4427591-A | TOPICAL ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1984-01-24 | — | — | US | disclosed |
| US-4336200-A | 17α-Acyloxy-5β-corticoids | THE UPJOHN COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4318853-A | ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4083974-A | Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether | THE UPJOHN COMPANY (US) | 1978-04-11 | — | — | US | disclosed |
| US-4018918-A | ANTIINFLAMMATORY, ANTIMICROBIAL AGENTS | THE UPJOHN COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
| US-4018918-A | ANTIINFLAMMATORY, ANTIMICROBIAL AGENTS | THE UPJOHN COMPANY (US) | 1977-04-19 | — | — | US | disclosed |
| US-3980778-A | Anti-inflammatory steroid | THE UPJOHN COMPANY (US) | 1976-09-14 | — | — | US | disclosed |