SCHEMBL4556005

SCHEMBL4556005

COC(=O)c1cccc(C)c1N(C)c1c(C)cccc1C(=O)OC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.48
NR4A2 P43354 1/20 0.47
LMNA P02545 1/20 0.47
TSHR P16473 1/20 0.47
ALDH1A1 P00352 4/20 0.46
HSD17B10 Q99714 2/20 0.46
CFTR P13569 1/20 0.46
KMT2A Q03164 3/20 0.45
KDM4E B2RXH2 4/20 0.44
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
MYC P01106 1/20 0.44
MAPT P10636 2/20 0.42
ALOX12 P18054 1/20 0.42
HTT P42858 1/20 0.42
S1PR4 O95977 1/20 0.41
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
CA12 O43570 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6645925 0.89 POLB (0.48) POLBNR4A2LMNATSHRALDH1A1
SCHEMBL27736140 0.81 TSHR (0.53) POLBLMNATSHRALDH1A1HSD17B10
SCHEMBL11421847 0.80 POLB (0.44) POLBNR4A2LMNATSHRALDH1A1
SCHEMBL9522854 0.80 POLB (0.44) POLBNR4A2LMNATSHRALDH1A1
SCHEMBL524457 0.77 LMNA (0.53) POLBNR4A2LMNATSHRALDH1A1
SCHEMBL29702037 0.77 TSHR (0.63) POLBNR4A2LMNATSHRALDH1A1
Dimethyl Phthalate SCHEMBL28079217 0.77 TSHR (0.63) POLBNR4A2LMNATSHRALDH1A1
SCHEMBL101601 0.77 TSHR (0.63) POLBNR4A2LMNATSHRALDH1A1
SCHEMBL31345289 0.76 NR4A2 (0.45) POLBNR4A2LMNATSHRALDH1A1
SCHEMBL699415 0.76 LMNA (0.52) POLBNR4A2LMNATSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2061754-A1 BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS XENON PHARMACEUTICALS INC. (CA) 2009-05-27 EP disclosed
WO-2008115999-A1 BIARYL AND BIHETEROARYL COMPOUNDS USEFUL IN TREATING IRON DISORDERS XENON PHARMACEUTICALS INC. (CA) 2008-09-25 WO disclosed