Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 13/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731935 | 0.86 | SMN1; SMN2 (0.43) | MCHR1 | |
| SCHEMBL731934 | 0.86 | SMN1; SMN2 (0.43) | MCHR1 | |
| SCHEMBL4446931 | 0.85 | KDM4E (0.48) | — | |
| SCHEMBL17443063 | 0.75 | KCNH2 (0.39) | — | |
| SCHEMBL8515681 | 0.74 | LPL (0.44) | — | |
| SCHEMBL5884467 | 0.73 | MCHR1 (0.65) | MCHR1 | |
| SCHEMBL731475 | 0.72 | KDR (0.49) | PIM1PIM2 | |
| SCHEMBL729951 | 0.71 | GPR119 (0.44) | — | |
| SCHEMBL729950 | 0.71 | GPR119 (0.44) | — | |
| SCHEMBL731052 | 0.71 | GRIN2B (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137184-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124323-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-10-16 | — | — | WO | disclosed |