Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL240111 | 0.85 | RAB9A (0.41) | EPHX2NR1H4HSD11B1KMT2A | |
| SCHEMBL237604 | 0.83 | EPHX2 (0.51) | EPHX2NR1H4HSD11B1PARP15PARP10 | |
| SCHEMBL241023 | 0.81 | EPHX2 (0.46) | L3MBTL1EPHX2HSD11B1HRH3KMT2A | |
| SCHEMBL239829 | 0.77 | RAB9A (0.43) | L3MBTL1EPHX2NR1H4PARP15PARP10 | |
| SCHEMBL242613 | 0.77 | EPHX2 (0.48) | L3MBTL1EPHX2HSD11B1HRH3KMT2A | |
| SCHEMBL240427 | 0.76 | PARP15 (0.49) | L3MBTL1EPHX2NR1H4HSD11B1PARP15 | |
| SCHEMBL242362 | 0.76 | EPHX2 (0.45) | L3MBTL1EPHX2HSD11B1HRH3KMT2A | |
| SCHEMBL239045 | 0.76 | HSD11B1 (0.40) | L3MBTL1EPHX2HSD11B1HRH3 | |
| SCHEMBL242960 | 0.75 | EPHX2 (0.49) | L3MBTL1EPHX2HSD11B1HRH3KMT2A | |
| SCHEMBL14402884 | 0.74 | RAB9A (0.38) | EPHX2NR1H4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010479-A1 | 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | High Point Pharmaceuticals, LLC (US) | 2009-01-07 | — | — | EP | claimed |
| WO-2007115935-A1 | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2007-10-18 | — | — | WO | claimed |