Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 18/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ME2 | P23368 | 2/20 | 0.36 |
| ▸ | ME1 | P48163 | 2/20 | 0.36 |
| ▸ | ME3 | Q16798 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556142 | 0.86 | HCAR2 (0.77) | HCAR2CYP2C9ME2ME1ME3 | |
| SCHEMBL4548329 | 0.85 | HCAR2 (1.00) | HCAR2CYP2C9 | |
| SCHEMBL4548412 | 0.74 | HCAR2 (0.61) | HCAR2CYP2C9ME2ME1ME3 | |
| SCHEMBL4556094 | 0.73 | HCAR2 (0.51) | HCAR2CYP2C9 | |
| SCHEMBL10312568 | 0.72 | HCAR2 (0.77) | HCAR2CYP2C9 | |
| SCHEMBL4556144 | 0.72 | HCAR2 (0.50) | HCAR2ME2ME1ME3 | |
| SCHEMBL13954053 | 0.69 | HCAR2 (0.60) | HCAR2CYP2C9 | |
| SCHEMBL4548410 | 0.69 | HCAR2 (0.59) | HCAR2CYP2C9 | |
| SCHEMBL13933981 | 0.66 | HCAR2 (0.68) | HCAR2CYP2C9 | |
| SCHEMBL4555523 | 0.63 | HCAR2 (0.76) | HCAR2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. (US) | 2012-07-12 | — | — | US | disclosed |
| US-8168649-B2 | Niacin receptor agonists, compositions containing such compounds and methods of treatment | Merk Sharp & Dohme Corp. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20100144778-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME LLC | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144778-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | HCAR1, HCAR2, GPR119 | HCAR2 2/4885CYP2C9 1081/4885ME2 1186/4885 |
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | HCAR1, HCAR2, FFAR1 | HCAR2 2/4885CYP2C9 1108/4885ME2 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.