⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazine SCHEMBL7600144 | 0.98 | — | — | |
| SCHEMBL2485392 | 0.82 | EGFR (0.30) | — | |
| SCHEMBL6690514 | 0.82 | EGFR (0.30) | — | |
| SCHEMBL9000091 | 0.79 | EGFR (0.32) | — | |
| SCHEMBL7064301 | 0.78 | — | — | |
| Laromustine SCHEMBL2416976 | 0.78 | CA12 (0.30) | — | |
| SCHEMBL9000086 | 0.78 | — | — | |
| SCHEMBL9000100 | 0.78 | TP53 (0.32) | — | |
| SCHEMBL7600141 | 0.78 | — | — | |
| SCHEMBL9000096 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804816-B1 | COMBINATION THERAPY COMPRISING CLORETAZINE(TM) | VION PHARMACEUTICALS INC (US) | 2011-12-21 | — | — | EP | disclosed |
| US-7605137-B2 | Combination therapy comprising cloretazine | VION PHARMACEUTICALS, INC. (US) | 2009-10-20 | — | — | US | disclosed |
| US-20080025984-A1 | Combination Therapy Comprising Cloretazine | NANOSHIFT, LLC | 2008-01-31 | — | — | US | disclosed |
| WO-2004098504-A3 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYL)HYDRAZINES AND METHODS OF TREATING TUMORS | UNIV YALE (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2004098504-A2 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYL)HYDRAZINES AND METHODS OF TREATING TUMORS | YALE UNIVERSITY (US) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004098504-A2 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYL)HYDRAZINES AND METHODS OF TREATING TUMORS | YALE UNIVERSITY (US) | 2004-11-18 | — | — | WO | disclosed |
| CN-1176067-C | Anti-tumor 2-amino-carboyl-1,2-di (methylsulfonyl)-1-(substituted) diazane | Ү³��ѧ | 2004-11-17 | — | — | CN | disclosed |
| CN-1405152-A | Anti-tumor 2-amino-carboyl-1,2-di (methylsulfonyl)-1-(substituted) diazane | UNIV YALE (US) | 2003-03-26 | — | — | CN | disclosed |
| CN-1095828-C | Antitumor 2-aminocarbonyl-1, 2-bis (methylsulfonyl) -1- (substituted) hydrazines | UNIV YALE (US) | 2002-12-11 | — | — | CN | disclosed |
| EP-0841912-B1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | UNIV YALE (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-0841912-B1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | UNIV YALE (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-0841912-A4 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | UNIV YALE (US) | 1998-10-14 | — | — | EP | disclosed |
| EP-0841912-A4 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | UNIV YALE (US) | 1998-10-14 | — | — | EP | disclosed |
| CN-1191482-A | Antitumor 2-aminocarbonyl-1, 2-bis (methylsulfonyl) -1- (substituted) hydrazines | UNIV YALE (US) | 1998-08-26 | — | — | CN | disclosed |
| EP-0841912-A1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | YALE UNIVERSITY (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0841912-A1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | YALE UNIVERSITY (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5637619-A | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines | YALE UNIVERSITY (US) | 1997-06-10 | — | — | US | disclosed |
| US-5637619-A | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines | YALE UNIVERSITY (US) | 1997-06-10 | — | — | US | disclosed |
| WO-1997002029-A1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | YALE UNIVERSITY (US) | 1997-01-23 | — | — | WO | disclosed |
| WO-1997002029-A1 | ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES | YALE UNIVERSITY (US) | 1997-01-23 | — | — | WO | disclosed |