Laromustine

Laromustine

SCHEMBL2416976

CNC(=O)N(N(CCCl)S(C)(=O)=O)S(C)(=O)=O

nearest known ligand 0.30

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7580472 0.83 MEN1 (0.45)
SCHEMBL7600141 0.81
SCHEMBL6690514 0.79 EGFR (0.30)
SCHEMBL2485392 0.79 EGFR (0.30)
SCHEMBL7064301 0.79
SCHEMBL4556547 0.78
Hydrazine SCHEMBL7600144 0.76
SCHEMBL9000091 0.76 EGFR (0.32)
SCHEMBL9000100 0.75 TP53 (0.32)
SCHEMBL9000086 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 385 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4640714-A2 METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST PML Screening, LLC (US) 2025-10-29 EP claimed
US-20250275946-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2025-09-04 US claimed
US-20250084059-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES INC (US) 2025-03-13 US claimed
EP-4177356-B1 METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST PML SCREENING LLC (US) 2024-05-08 EP claimed
EP-3947375-B1 IMIDAZOLONYLQUINOLINE COMPOUNDS AND THERAPEUTIC USES THEREOF MERCK PATENT GMBH (DE) 2024-04-03 EP claimed
EP-4177356-A1 METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST PML Screening, LLC (US) 2023-05-10 EP claimed
US-20230137849-A1 USE OF A COMPOUND OF THE DIURETICS CLASS FOR TREATING CANCER AZELEAD (FR) 2023-05-04 US claimed
EP-3625368-B1 METHODS FOR ASSESSING THE RISK OF DEVELOPING PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY CAUSED BY JOHN CUNNINGHAM VIRUS BY GENETIC TESTING PML SCREENING LLC (US) 2022-11-09 EP claimed
WO-2022169634-A9 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2022-09-22 WO claimed
WO-2022177302-A1 PYRIMIDINE-FUSED RING COMPOUND WITH DNA-PK INHIBITION ACTIVITY AND USE THEREOF 보령제약 주식회사 2022-08-25 WO claimed
WO-2022169634-A1 COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNM RAINFOREST INNOVATIONS (US) 2022-08-11 WO claimed
EP-1804816-B1 COMBINATION THERAPY COMPRISING CLORETAZINE(TM) VION PHARMACEUTICALS INC (US) 2011-12-21 EP claimed
US-7605137-B2 Combination therapy comprising cloretazine VION PHARMACEUTICALS, INC. (US) 2009-10-20 US claimed
US-12637492-B2 Peptide inhibitors of focal adhesion kinase activity and uses thereof ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2026-05-26 US disclosed
US-12637415-B2 Lyophilized composition comprising (s)-isopropyl 2-((s)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate for intravenous administration and the use thereof DRACEN PHARMACEUTICALS, INC. (US) 2026-05-26 US disclosed
US-20260137698-A1 CYCLIN-DEPENDENT KINASE 7 INHIBITORS JOINT STOCK CO «BIOCAD» (RU) 2026-05-21 US disclosed
CN-1191482-A Antitumor 2-aminocarbonyl-1, 2-bis (methylsulfonyl) -1- (substituted) hydrazines UNIV YALE (US) 1998-08-26 CN disclosed
EP-0841912-A1 ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES YALE UNIVERSITY (US) 1998-05-20 EP disclosed
US-5637619-A Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines YALE UNIVERSITY (US) 1997-06-10 US disclosed
WO-1997002029-A1 ANTITUMOR 2-AMINOCARBONYL-1,2-BIS(METHYLSULFONYL)-1-(SUBSTITUTED)HYDRAZINES YALE UNIVERSITY (US) 1997-01-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250084059-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 CA12 25/4885CA1 61/4885CA9 24/4885
US-20260137698-A1 CYCLIN-DEPENDENT KINASE 7 INHIBITORS CDK7, CDK6, CDK3 CA12 3596/4885CA1 2214/4885CA9 1360/4885
US-20230137849-A1 USE OF A COMPOUND OF THE DIURETICS CLASS FOR TREATING CANCER ABCC4, ATP6V1B1, ABCC2 CA12 239/4885CA1 743/4885CA9 137/4885
US-12637492-B2 Peptide inhibitors of focal adhesion kinase activity and uses thereof PTK2, ILK, FPR2 CA12 4778/4885CA1 4827/4885CA9 4769/4885
US-12637415-B2 Lyophilized composition comprising (s)-isopropyl 2-((s)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo-5-oxohexanoate for intravenous administration and the use thereof GLS, GLUL, GLS2 CA12 2905/4885CA1 1694/4885CA9 3091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.