Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885578 | 0.92 | MEN1 (0.41) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL2885604 | 0.90 | UCHL1 (0.47) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL3902861 | 0.82 | UCHL1 (0.52) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL31014046 | 0.82 | UCHL1 (0.52) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL30147617 | 0.78 | UCHL1 (0.61) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL20571008 | 0.78 | UCHL1 (0.61) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL868725 | 0.76 | NOTUM (0.65) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL20571049 | 0.76 | UCHL1 (0.46) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL3502782 | 0.75 | UCHL1 (0.45) | UCHL1HDAC1HDAC6NOTUMKDM1A | |
| SCHEMBL2885921 | 0.75 | NOTUM (0.47) | UCHL1HDAC1HDAC6NOTUMKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121638-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076225-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2008-06-26 | — | — | WO | disclosed |