Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.71 |
| ▸ | TP53 | P04637 | 4/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | MTOR | P42345 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | THPO | P40225 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | GMNN | O75496 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indatraline SCHEMBL585770 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| (R,S)-Indatraline SCHEMBL9252640 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL29516308 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL11128740 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| (R,S)-Indatraline SCHEMBL31307192 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL9252635 | 0.84 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| SCHEMBL6944925 | 0.83 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| SCHEMBL813054 | 0.83 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL5436564 | 0.82 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 | |
| Indatraline SCHEMBL467134 | 0.82 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253932-A1 | Resolution of Racemic Organic Acids with (1S, 4S)-4[3,4-Dichlorophenyl]-1,2,3,4-Tetrahydro-N-Methyl-1-Naphthaloneamine | MATRIX LABORATORIES LTD (IN) | 2009-10-08 | — | — | US | claimed |
| EP-1831132-A2 | RESOLUTION OF RACEMIC ORGANIC ACIDS WITH (1S, 4S)-4[3,4-DICHLOROPHENYL]-1,2,3,4- TETRAHYDRO-N-METHYL-1-NAPHTHALONEAMINE | Matrix Laboratories Ltd (IN) | 2007-09-12 | — | — | EP | claimed |
| WO-2006013581-A2 | RESOLUTION OF RACEMIC ORGANIC ACIDS WITH (1S, 4S)-4[3,4-DICHLOROPHENYL]-1,2,3,4- TETRAHYDRO-N-METHYL-1-NAPHTHALONEAMINE | MATRIX LABORATORIES LTD (IN) | 2006-02-09 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253932-A1 | Resolution of Racemic Organic Acids with (1S, 4S)-4[3,4-Dichlorophenyl]-1,2,3,4-Tetrahydro-N-Methyl-1-Naphthaloneamine | HTR4, OXER1, CYP2S1 | SLC6A2 659/4885SLC6A4 75/4885SLC6A3 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.