Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644052 | 0.82 | HRH3 (0.54) | HRH3HPGDTP53MEN1KMT2A | |
| SCHEMBL1285141 | 0.81 | HRH3 (0.53) | HRH3MAP4K4NPC1MITFTP53 | |
| SCHEMBL1644303 | 0.80 | HRH3 (0.53) | HRH3HPGDTP53MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL18109905 | 0.80 | HTR3A (0.60) | HRH3TP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4307874 | 0.79 | HRH3 (0.52) | PTGER4HRH3TP53 | |
| SCHEMBL1645114 | 0.78 | PIK3CA (0.58) | HRH3HPGDMEN1KMT2A | |
| SCHEMBL14575817 | 0.78 | HRH3 (0.63) | PTGER4HRH3NPC1RAB9AKMT2A | |
| SCHEMBL12302240 | 0.78 | ALDH1A1 (0.56) | HRH3HPGDNPC1MITFTP53 | |
| SCHEMBL27109013 | 0.78 | ACACB (0.49) | HRH3GRM1TP53MEN1KMT2A | |
| SCHEMBL27110450 | 0.77 | PDE10A (0.53) | HRH3GRM1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024272-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2007133637-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-11-22 | — | — | WO | claimed |