Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216707 | 0.92 | PTPN1 (0.46) | PTPN1TBXAS1KMT2ACYP19A1PTPN2 | |
| SCHEMBL4782763 | 0.79 | PTPN1 (0.46) | PTPN1PTPN2 | |
| SCHEMBL4557565 | 0.76 | PTPN1 (0.44) | PTPN1PTPN2 | |
| SCHEMBL4461683 | 0.76 | PTPN1 (0.44) | PTPN1PTPN2 | |
| SCHEMBL3216140 | 0.75 | PTPN1 (0.46) | PTPN1PTPN2 | |
| SCHEMBL4782346 | 0.74 | PTPN1 (0.39) | PTPN1PTPN2 | |
| SCHEMBL3216584 | 0.72 | PTPN1 (0.50) | PTPN1TBXAS1PTPN2 | |
| SCHEMBL2933680 | 0.72 | PTPN1 (0.54) | PTPN1PTPN2TP53CYP1A2CYP3A4 | |
| SCHEMBL3916808 | 0.72 | PTPN1 (0.55) | PTPN1PTPN2 | |
| SCHEMBL4557101 | 0.71 | PTPN1 (0.42) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |