Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 9/20 | 0.33 |
| ▸ | DAO | P14920 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | COMT | P21964 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223283 | 0.92 | PTPN1 (0.49) | PTPN1PTPN2DAOCOMT | |
| SCHEMBL4733377 | 0.87 | PTPN1 (0.51) | PTPN1PTPN2 | |
| SCHEMBL3216277 | 0.84 | PTPN1 (0.49) | PTPN1PTPN2DAOCOMT | |
| SCHEMBL4782763 | 0.81 | PTPN1 (0.46) | PTPN1PTPN2 | |
| SCHEMBL3214274 | 0.81 | PTPN1 (0.52) | PTPN1PTPN2DAO | |
| SCHEMBL4316679 | 0.81 | PTPN1 (0.57) | PTPN1PTPN2DAO | |
| SCHEMBL3208657 | 0.78 | PTPN1 (0.58) | PTPN1PTPN2 | |
| SCHEMBL4556365 | 0.77 | PTPN1 (0.44) | PTPN1PTPN2DAO | |
| SCHEMBL4557290 | 0.76 | PTPN1 (0.40) | PTPN1PTPN2 | |
| SCHEMBL3916808 | 0.76 | PTPN1 (0.55) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089026-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | Novartis AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008070552-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE PROMOTION OF PHYSIOLOGICAL CARDIAC HYPERTROPHY | NOVARTIS AG (CH) | 2008-06-12 | — | — | WO | disclosed |