Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4939376 | 0.89 | SCN9A (0.47) | SCN9AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4597085 | 0.87 | SCN9A (0.48) | SCN9AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4595630 | 0.81 | ALDH1A1 (0.53) | SCN9AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4597663 | 0.81 | ALDH1A1 (0.55) | SCN9AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL484051 | 0.81 | SCN9A (0.58) | SCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL281905 | 0.81 | SCN9A (0.48) | SCN9AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3007855 | 0.80 | SCN9A (0.52) | SCN9AALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1612150 | 0.80 | SCN9A (0.56) | SCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL15314921 | 0.79 | SCN9A (0.50) | SCN9AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL14506505 | 0.78 | ALDH1A1 (0.52) | SCN9AALDH1A1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073806-A2 | USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008060789-A2 | USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-05-22 | — | — | WO | disclosed |