Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 12/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595630 | 0.91 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL27707822 | 0.91 | SCN9A (0.51) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL281589 | 0.89 | SCN9A (0.50) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL4597085 | 0.86 | SCN9A (0.48) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL3007855 | 0.84 | SCN9A (0.52) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL1612150 | 0.84 | SCN9A (0.56) | ALDH1A1MEN1KMT2ASCN9A | |
| SCHEMBL27707824 | 0.84 | SCN9A (0.49) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL281721 | 0.82 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL4939376 | 0.82 | SCN9A (0.47) | ALDH1A1MEN1KMT2ASCN9AGAA | |
| SCHEMBL4557308 | 0.81 | SCN9A (0.47) | ALDH1A1MEN1KMT2ASCN9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | claimed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | claimed |
| WO-2008046083-A2 | USE OF OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-04-17 | — | — | WO | disclosed |