Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | APAF1 | O14727 | 1/20 | 0.73 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.73 |
| ▸ | FDPS | P14324 | 15/20 | 0.39 |
| ▸ | PON1 | P27169 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL17273624 | 0.98 | MEN1 (0.76) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| Iodide SCHEMBL3697966 | 0.96 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| Iodide SCHEMBL412962 | 0.96 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| Bromide SCHEMBL33528969 | 0.94 | SMN1; SMN2 (0.82) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL34969 | 0.94 | MEN1 (0.81) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| Water SCHEMBL602794 | 0.92 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2580666 | 0.92 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL36719 | 0.92 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL20957483 | 0.92 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL14841603 | 0.92 | MEN1 (0.79) | MEN1HSP90AA1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501779-B1 | CONTINUOUS CARBONYLATION PROCESS | EASTMAN CHEM CO (US) | 2009-12-23 | — | — | EP | disclosed |
| US-6916951-B2 | Continuous carbonylation process | EASTMAN CHEMICAL COMPANY (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1501779-A1 | CONTINUOUS CARBONYLATION PROCESS | EASTMAN CHEMICAL COMPANY (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093211-A1 | CONTINUOUS CARBONYLATION PROCESS | EASTMAN CHEMICAL COMPANY (US) | 2003-11-13 | — | — | WO | disclosed |
| US-20030212295-A1 | Continuous carbonylation process | EASTMAN CHEMICAL COMPANY | 2003-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212295-A1 | Continuous carbonylation process | CA4, CA5B, CA14 | MEN1 2843/4885HSP90AA1 2383/4885KMT2A 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.