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Sugi Predict / Targets / CA5B

CA5B

Carbonic anhydrase 5B, mitochondrial · Q9Y2D0 · CA5B on Sugi Atlas →

188,409 patent compounds predicted against CA5B, 117,510 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Mafenide Mafenide (SCHEMBL41627) 0.77 8/20
SCHEMBL19880 SCHEMBL19880 0.55 8/20
Benzthiazide Benzthiazide (SCHEMBL26257) 0.42 8/20
SCHEMBL35394 SCHEMBL35394 0.48 7/20
SCHEMBL8588 SCHEMBL8588 0.43 7/20
SCHEMBL42927 SCHEMBL42927 0.87 6/20
SCHEMBL34781 SCHEMBL34781 0.51 6/20
SCHEMBL16810 SCHEMBL16810 0.42 6/20
Benzthiazide Benzthiazide (SCHEMBL26258) 0.42 6/20
Benzenesulfonamide Benzenesulfonamide (SCHEMBL729) 1.00 5/20
Sulfanilamide Sulfanilamide (SCHEMBL740) 1.00 5/20
Coumarin Coumarin (SCHEMBL6252) 1.00 5/20
Spermine Spermine (SCHEMBL14965) 1.00 5/20
Trientine Trientine (SCHEMBL15439) 1.00 5/20
Spermidine Spermidine (SCHEMBL15618) 1.00 5/20
SCHEMBL15797 SCHEMBL15797 1.00 5/20
SCHEMBL26707 SCHEMBL26707 1.00 5/20
SCHEMBL28170 SCHEMBL28170 1.00 5/20
Mafenide Mafenide (SCHEMBL41628) 1.00 5/20
SCHEMBL20976 SCHEMBL20976 0.86 5/20

Clinical trials — most relevant to CA5B by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Dexmedetomidine Effect on Mitochondrial Function PHASE4UNKNOWN
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression PHASE2/PHASE3NOT_YET_RECRUITING
Clinical Evaluation of the Effect of Metformin in Sepsis PHASE3UNKNOWN
The Effect of Combination Ultra Q10 and L-carnitine on the Course of Myelodysplastic Syndrome PHASE2/PHASE3UNKNOWN
DHA For The Treatment of Pediatric Concussion Related to Sports Injury PHASE1COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Human Adaptation to High Altitude nanUNKNOWN
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome nanCOMPLETED
Angiogenesis Induced in the Elderly by Hyperbaric Oxygen Therapy nanCOMPLETED
The Crosstalk Between the Epigenome and Mitochondria in SCI nanNOT_YET_RECRUITING
Risk Factors Associated With High Altitude Sickness: A Case-Control Study nanCOMPLETED
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Effect of Exercise Training on Protein Expression in Skeletal Muscle Tissue After Exercise in Peripheral Arterial Disease nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders nanRECRUITING
Saturated Fat Versus Monounsaturated Fat and Insulin Action nanCOMPLETED
Combined Intracerebral and Jugular Bulb Microdialysis nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Traumatic Brain Injury in Veterans and Near-Infrared Phototherapy nanCOMPLETED
Functional Mitochondrial Analysis PBMCs nanACTIVE_NOT_RECRUITING
Development of Novel Therapies for NIDDM nanCOMPLETED
The Etiology and Progression of Brain Tumors nanCOMPLETED
Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19 nanUNKNOWN
Mitochondrial Function in the Peri-operative Setting: an Observational Study nanNOT_YET_RECRUITING
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men nanUNKNOWN
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a CA5B binder may also engage these)

ProteinNameSimilarity
Q66HG6 — 1.000 Q66HG6 →
Q9QZA0 — 1.000 Q9QZA0 →
P43165 — 0.983 P43165 →
CA5A Carbonic anhydrase 5A, mitochondrial 0.979 landscape →
P23589 — 0.979 P23589 →
P16015 — 0.960 P16015 →
Q5S1S4 — 0.957 Q5S1S4 →
P14141 — 0.953 P14141 →
CA3 Carbonic anhydrase 3 0.953 landscape →
Q9D6N1 — 0.948 Q9D6N1 →
Q8VDG3 — 0.947 Q8VDG3 →
Q14CH1 — 0.947 Q14CH1 →
Q6GR37 — 0.946 Q6GR37 →
Q96EN8 — 0.946 Q96EN8 →
PARN Poly(A)-specific ribonuclease PARN 0.945 landscape →
Q5RC51 — 0.943 Q5RC51 →
Q8BSF4 — 0.941 Q8BSF4 →
Q8R1R3 — 0.941 Q8R1R3 →
P61798 — 0.941 P61798 →
CA13 Carbonic anhydrase 13 0.941 landscape →
Q1HFZ0 — 0.940 Q1HFZ0 →
Q9UG56 — 0.940 Q9UG56 →
P69341 — 0.940 P69341 →
Q6GQ33 — 0.940 Q6GQ33 →
Q9N0E7 — 0.940 Q9N0E7 →
O95671 — 0.940 O95671 →
Q8BHD4 — 0.939 Q8BHD4 →
Q7Z2E3 — 0.939 Q7Z2E3 →
Q5R803 — 0.939 Q5R803 →
Q5R8I8 — 0.939 Q5R8I8 →