Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.73 |
| ▸ | SRC | P12931 | 4/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.51 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557892 | 0.87 | MAP2K1 (0.73) | MAP2K1SRCEGFRFGFR2KDR | |
| SCHEMBL4558340 | 0.86 | MAP2K1 (0.71) | MAP2K1SRCEGFRFGFR2KDR | |
| SCHEMBL4448999 | 0.85 | MAP2K1 (1.00) | MAP2K1EGFR | |
| SCHEMBL4447904 | 0.83 | MAP2K1 (0.72) | MAP2K1SRCEGFRFGFR2KDR | |
| SCHEMBL18828353 | 0.83 | SRC (0.57) | MAP2K1SRCEGFRFGFR2KDR | |
| SCHEMBL12308286 | 0.80 | EGFR (0.77) | SRCEGFRKDRMET | |
| SCHEMBL27731209 | 0.80 | KDR (0.62) | SRCEGFRKDRMET | |
| SCHEMBL4445567 | 0.80 | SRC (0.62) | MAP2K1SRCEGFRFGFR2KDR | |
| SCHEMBL4447835 | 0.79 | MAP2K1 (0.64) | MAP2K1SRCFGFR2KDRMET | |
| SCHEMBL12469296 | 0.76 | AXL (0.73) | SRCEGFRKDREHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151910-A2 | COMBINATION PRODUCT OF RECEPTOR TYROSINE KINASE INHIBITOR AND FATTY ACID SYNTHASE INHIBITOR FOR TREATING CANCER | WYETH (US) | 2009-12-17 | — | — | WO | disclosed |