Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 10/20 | 0.73 |
| ▸ | SRC | P12931 | 8/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.53 |
| ▸ | STK17B | O94768 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558340 | 0.88 | MAP2K1 (0.71) | MAP2K1SRCKDREGFRLCK | |
| SCHEMBL4557789 | 0.87 | MAP2K1 (0.73) | MAP2K1SRCKDREGFRMET | |
| SCHEMBL4456367 | 0.85 | MAP2K1 (1.00) | MAP2K1SRCEGFRERBB2 | |
| SCHEMBL27731209 | 0.83 | KDR (0.62) | SRCKDREGFRCITGAK | |
| SCHEMBL4447904 | 0.83 | MAP2K1 (0.72) | MAP2K1SRCKDREGFRLCK | |
| SCHEMBL18828353 | 0.83 | SRC (0.57) | MAP2K1SRCKDREGFRCIT | |
| SCHEMBL12308286 | 0.82 | EGFR (0.77) | SRCKDREGFRCITGAK | |
| SCHEMBL4445567 | 0.82 | SRC (0.62) | MAP2K1SRCKDREGFRLCK | |
| SCHEMBL4447835 | 0.81 | MAP2K1 (0.64) | MAP2K1SRCKDRLCKMET | |
| SCHEMBL6431410 | 0.78 | EGFR (0.78) | SRCKDREGFRCITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151910-A2 | COMBINATION PRODUCT OF RECEPTOR TYROSINE KINASE INHIBITOR AND FATTY ACID SYNTHASE INHIBITOR FOR TREATING CANCER | WYETH (US) | 2009-12-17 | — | — | WO | disclosed |