Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.71 |
| ▸ | SRC | P12931 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | TTK | P33981 | 1/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557892 | 0.88 | MAP2K1 (0.73) | MAP2K1SRCKDREGFRMET | |
| SCHEMBL4557789 | 0.86 | MAP2K1 (0.73) | MAP2K1SRCKDREGFRMET | |
| SCHEMBL4445567 | 0.85 | SRC (0.62) | MAP2K1SRCKDREGFRMET | |
| SCHEMBL4447904 | 0.85 | MAP2K1 (0.72) | MAP2K1SRCKDREGFRMET | |
| SCHEMBL18828353 | 0.85 | SRC (0.57) | MAP2K1SRCKDREGFRMET | |
| SCHEMBL27731209 | 0.84 | KDR (0.62) | SRCKDREGFRMETLCK | |
| SCHEMBL4447835 | 0.83 | MAP2K1 (0.64) | MAP2K1SRCKDRMETRAF1 | |
| SCHEMBL4457381 | 0.83 | MAP2K1 (1.00) | MAP2K1EGFRRAF1MAPK3MAPK1 | |
| SCHEMBL12308286 | 0.82 | EGFR (0.77) | SRCKDREGFRMETLCK | |
| SCHEMBL3911219 | 0.79 | FLT3 (0.74) | MAP2K1SRCKDREGFRMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009151910-A2 | COMBINATION PRODUCT OF RECEPTOR TYROSINE KINASE INHIBITOR AND FATTY ACID SYNTHASE INHIBITOR FOR TREATING CANCER | WYETH (US) | 2009-12-17 | — | — | WO | disclosed |