Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10540791 | 0.82 | P2RX7 (0.46) | P2RX7SLC6A2SLC6A4IDO1NOTUM | |
| SCHEMBL1635491 | 0.82 | PNMT (0.54) | P2RX7SLC6A2SLC6A4IDO1NOTUM | |
| SCHEMBL10747351 | 0.82 | P2RX7 (0.46) | P2RX7SLC6A2SLC6A4IDO1NOTUM | |
| SCHEMBL2632854 | 0.80 | P2RX7 (0.49) | P2RX7SLC6A2SLC6A4 | |
| SCHEMBL3283101 | 0.80 | P2RX7 (0.44) | P2RX7SLC6A2SLC6A4 | |
| SCHEMBL29129467 | 0.80 | P2RX7 (0.44) | P2RX7SLC6A2SLC6A4IDO1NOTUM | |
| SCHEMBL488470 | 0.80 | P2RX7 (0.53) | P2RX7SLC6A2SLC6A4IDO1NOTUM | |
| SCHEMBL1043059 | 0.78 | P2RX7 (0.57) | P2RX7IDO1NOTUM | |
| SCHEMBL25089767 | 0.77 | P2RX7 (0.42) | P2RX7SLC6A2SLC6A4IDO1NOTUM | |
| SCHEMBL15532421 | 0.77 | TRPV1 (0.43) | P2RX7SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074518-A1 | COMBINATIONS OF PROLINAMIDE P2X7 MODULATORS WITH FURTHER THERAPEUTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |