Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603072 | 0.91 | JAK2 (0.54) | JAK2HDAC1HDAC6JAK3GSK3B | |
| SCHEMBL4382278 | 0.88 | JAK2 (0.72) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL4762218 | 0.88 | JAK2 (0.70) | JAK2HDAC1HDAC6JAK3GSK3B | |
| SCHEMBL4603101 | 0.83 | JAK2 (0.55) | JAK2HDAC1HDAC6JAK3GSK3B | |
| SCHEMBL4384202 | 0.81 | JAK2 (0.69) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL4602091 | 0.80 | GSK3B (0.57) | JAK2HDAC1HDAC6JAK3GSK3B | |
| SCHEMBL4600894 | 0.78 | CCNT1 (0.51) | JAK2JAK3GSK3BMAPK8PIK3CG | |
| SCHEMBL4375224 | 0.78 | JAK2 (0.77) | JAK2HDAC1HDAC6JAK3CDK2 | |
| SCHEMBL4558034 | 0.77 | JAK2 (0.58) | JAK2HDAC1HDAC6JAK3GSK3B | |
| SCHEMBL3753315 | 0.77 | MAPK8 (0.62) | JAK2JAK3GSK3BMAPK8PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979329-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |