Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.54 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.44 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801393 | 0.84 | JAK2 (0.69) | JAK2JAK3IGF1RCCNT1CDK9 | |
| SCHEMBL13588456 | 0.81 | JAK2 (0.67) | JAK2JAK3IGF1RCCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL4383810 | 0.81 | JAK2 (0.66) | JAK2JAK3IGF1RCCNT1CDK9 | |
| SCHEMBL4592600 | 0.80 | CCNT1 (0.57) | JAK2JAK3IGF1RCCNT1CDK9 | |
| SCHEMBL8093455 | 0.77 | JAK2 (0.61) | JAK2JAK3IGF1RCCNT1CDK9 | |
| SCHEMBL4159803 | 0.77 | CDK2 (0.72) | JAK2JAK3IGF1RCCNT1CDK9 | |
| SCHEMBL4376766 | 0.76 | JAK2 (0.72) | JAK2JAK3IGF1RCCNT1CDK9 | |
| SCHEMBL12801232 | 0.75 | JAK2 (0.61) | JAK2JAK3IGF1RZAP70TNIK | |
| SCHEMBL1668203 | 0.75 | JAK2 (0.59) | JAK2JAK3IGF1RZAP70TNIK | |
| SCHEMBL4159168 | 0.75 | CDK2 (0.71) | JAK2JAK3IGF1RCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |