Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 8/20 | 0.57 |
| ▸ | CDK9 | P50750 | 8/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.57 |
| ▸ | CDK2 | P24941 | 6/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13588456 | 0.81 | JAK2 (0.67) | CCNT1CDK9IGF1RTNIKKCNH2 | |
| Hydrochloric Acid SCHEMBL4383810 | 0.80 | JAK2 (0.66) | CCNT1CDK9IGF1RTNIKKCNH2 | |
| SCHEMBL8093455 | 0.80 | JAK2 (0.61) | CCNT1CDK9CDK2IGF1RTNIK | |
| SCHEMBL4558092 | 0.80 | JAK2 (0.54) | CCNT1CDK9CCNA2CDK2IGF1R | |
| SCHEMBL4518606 | 0.79 | CCNT1 (0.60) | CCNT1CDK9CCNA2CDK2IGF1R | |
| SCHEMBL1668203 | 0.79 | JAK2 (0.59) | IGF1RTNIKKCNH2JAK2JAK3 | |
| SCHEMBL4159168 | 0.78 | CDK2 (0.71) | CCNT1CDK9CCNA2CDK2IGF1R | |
| SCHEMBL4376766 | 0.78 | JAK2 (0.72) | CCNT1CDK9IGF1RJAK2JAK3 | |
| SCHEMBL4159803 | 0.77 | CDK2 (0.72) | CCNT1CDK9CCNA2CDK2IGF1R | |
| SCHEMBL12801393 | 0.77 | JAK2 (0.69) | CCNT1CDK9IGF1RTNIKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |