Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.46 |
| ▸ | HTR3B | O95264 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452291 | 0.88 | BACE1 (0.62) | BACE1TAAR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13962883 | 0.88 | BACE1 (0.62) | BACE1RPS6KB1HTR3EHTR3BHTR3A | |
| SCHEMBL13962869 | 0.86 | BACE1 (0.60) | BACE1TAAR1KMT2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4603331 | 0.86 | BACE1 (0.60) | BACE1TAAR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9830326 | 0.84 | NR3C2 (0.54) | BACE1RPS6KB1TAAR1KDM4EPARP1 | |
| SCHEMBL14012061 | 0.83 | BACE1 (0.56) | BACE1TAAR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11182436 | 0.83 | KDM4E (0.47) | RPS6KB1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL4606123 | 0.80 | BACE1 (0.53) | BACE1TAAR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6948731 | 0.80 | BACE1 (0.53) | BACE1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL7656556 | 0.80 | GRM4 (0.55) | BACE1KMT2AMEN1NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107556237-B | Preparation method of 3- (2-phenethyl) -2-pyridine carboxamide compound | 四川大学 | 2020-11-24 | — | — | CN | disclosed |
| US-20090005567-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO (5,6)-CYCLOHEPTA-(1,2B) -PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZACH SYSTEM S.P.A. (IT) | 2009-01-01 | — | — | US | disclosed |
| US-7449583-B2 | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) | ZACH SYSTEM S.P.A. (IT) | 2008-11-11 | — | — | US | disclosed |
| US-20050171352-A1 | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) | ZAMBON GROUP S.P.A (IT) | 2005-08-04 | — | — | US | disclosed |
| EP-1442035-A1 | PROCESS FOR THE PREPARATION OF 4- (8-CHLORO-5, 6-DIHYDRO-11H-BENZO-[5,6]-CYCLOHEPTA-[1,2-B]-PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZAMBON GROUP S.p.A. (IT) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003040140-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)-CYCLOHEPTA-(1,2B)-PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLI C ACID ETHYL ESTER (LORATADINE) | ZAMBON GROUP S.P.A. (IT) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005567-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO (5,6)-CYCLOHEPTA-(1,2B) -PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | HRH4, HRH2, GRIN3A | BACE1 3426/4885RPS6KB1 2759/4885HTR3E 145/4885 |
| US-20050171352-A1 | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) | HRH4, HRH2, HRH1 | BACE1 3974/4885RPS6KB1 2010/4885HTR3E 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.