Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948731 | 0.93 | BACE1 (0.53) | GRM4BACE1HDAC6KDM4EMAPT | |
| SCHEMBL14012061 | 0.84 | BACE1 (0.56) | GRM4BACE1HDAC6KDM4EMAPT | |
| SCHEMBL4452291 | 0.84 | BACE1 (0.62) | GRM4BACE1KDM4EMAPTGAA | |
| Hydrochloric Acid SCHEMBL4603331 | 0.83 | BACE1 (0.60) | GRM4BACE1KDM4EMAPTGAA | |
| SCHEMBL4606123 | 0.81 | BACE1 (0.53) | GRM4BACE1HDAC6KDM4EMAPT | |
| SCHEMBL13962883 | 0.81 | BACE1 (0.62) | GRM4BACE1HDAC6GAAALDH1A1 | |
| SCHEMBL4558113 | 0.80 | BACE1 (0.64) | GRM4BACE1HDAC6KDM4EGAA | |
| SCHEMBL13962869 | 0.80 | BACE1 (0.60) | GRM4BACE1HDAC6KDM4EMAPT | |
| SCHEMBL5743593 | 0.73 | BACE1 (0.58) | BACE1MAPTGAAALDH1A1PPIA | |
| SCHEMBL19539578 | 0.73 | ALDH1A1 (0.47) | HDAC6KDM4EMAPTALDH1A1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495689-B2 | DEHYDRATING COMPOUND COMPRISING 2-AMIDO ARYL OR HETEROARYL-3-ETHYLPHENYL-PYRIDINE COMPOUND TO FORM IMINE DERIVATIVE; HYDROLYSIS TO FORM (SUBSTITUTED) 5,6-DIHYDRO-11HBENZO(5,6)CYCLOHEPTA(1,2B)PYRID-11-ONE COMPOUND | SCHERING CORPORATION | 2002-12-17 | — | — | US | disclosed |
| US-20020077331-A1 | Synthesis of intermediates useful in preparing tricyclic compounds | MERCK SHARP & DOHME CORP. | 2002-06-20 | — | — | US | disclosed |
| US-6372909-B1 | REACTING 3-PHENYLETHYL-2-PYRIDINECARBOXAMIDE WITH DEHYDRATING AGENT TO CYCLIZE AND FORM TRICYCLIC IMINE, HYDROLYZING TO FORM TRICYCLIC KETONE | SCHERING CORPORATION | 2002-04-16 | — | — | US | disclosed |
| EP-1131296-A2 | SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING TRICYCLIC COMPOUNDS | SCHERING CORPORATION (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000030589-A2 | SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING TRICYCLIC COMPOUNDS | SCHERING CORPORATION (US) | 2000-06-02 | — | — | WO | disclosed |
| US-4873335-A | 3-phenethyl-2-benzene-amides or aza-derivatives thereof | SCHERING CORPORATION (US) | 1989-10-10 | — | — | US | disclosed |
| US-4731447-A | Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof | SCHERING CORPORATION (US) | 1988-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077331-A1 | Synthesis of intermediates useful in preparing tricyclic compounds | CBR1, CYP2F1, REV1 | GRM4 2273/4885BACE1 2672/4885HDAC6 2104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.