Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4603331 | 0.99 | BACE1 (0.60) | BACE1KDM4EMAPTCYP1A2KDM4C | |
| SCHEMBL13962883 | 0.89 | BACE1 (0.62) | BACE1KDM4CKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13962869 | 0.88 | BACE1 (0.60) | BACE1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL4558113 | 0.88 | BACE1 (0.64) | BACE1KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14012061 | 0.84 | BACE1 (0.56) | BACE1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL7656556 | 0.84 | GRM4 (0.55) | BACE1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL10749832 | 0.84 | KDM4E (0.62) | KDM4EMAPTCYP1A2SMN1; SMN2NPC1 | |
| SCHEMBL9829635 | 0.83 | KDM4E (0.51) | BACE1KDM4EMAPTCYP1A2KDM4C | |
| SCHEMBL13962897 | 0.83 | KDM4E (0.51) | BACE1KDM4EMAPTCYP1A2KMT2A | |
| SCHEMBL4606123 | 0.81 | BACE1 (0.53) | BACE1KDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105566214-B | Preparation process of 3- [2- (3-chlorphenyl) ethyl ] -2-picolinic acid | 上海医药工业研究院 | 2020-05-15 | — | — | CN | claimed |
| US-20090005567-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO (5,6)-CYCLOHEPTA-(1,2B) -PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZACH SYSTEM S.P.A. (IT) | 2009-01-01 | — | — | US | claimed |
| EP-1442035-B1 | PROCESS FOR THE PREPARATION OF 4- (8-CHLORO-5, 6-DIHYDRO-11H-BENZO-[5,6]-CYCLOHEPTA-[1,2-B]-PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZAMBON SPA (IT) | 2006-01-11 | — | — | EP | claimed |
| US-20050171352-A1 | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) | ZAMBON GROUP S.P.A (IT) | 2005-08-04 | — | — | US | claimed |
| EP-1442035-A1 | PROCESS FOR THE PREPARATION OF 4- (8-CHLORO-5, 6-DIHYDRO-11H-BENZO-[5,6]-CYCLOHEPTA-[1,2-B]-PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZAMBON GROUP S.p.A. (IT) | 2004-08-04 | — | — | EP | claimed |
| WO-2003040140-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)-CYCLOHEPTA-(1,2B)-PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLI C ACID ETHYL ESTER (LORATADINE) | ZAMBON GROUP S.P.A. (IT) | 2003-05-15 | — | — | WO | claimed |
| CN-105566214-B | Preparation process of 3- [2- (3-chlorphenyl) ethyl ] -2-picolinic acid | 上海医药工业研究院 | 2020-05-15 | — | — | CN | disclosed |
| CN-105566214-B | Preparation process of 3- [2- (3-chlorphenyl) ethyl ] -2-picolinic acid | 上海医药工业研究院 | 2020-05-15 | — | — | CN | disclosed |
| CN-105566214-B | Preparation process of 3- [2- (3-chlorphenyl) ethyl ] -2-picolinic acid | 上海医药工业研究院 | 2020-05-15 | — | — | CN | disclosed |
| CN-105566214-A | Preparation process of 3-[2-(3-chlorphenyl)ethyl]-2-pyridinecarboxylic acid | SHANGHAI INST PHARMACEUTICAL IND | 2016-05-11 | — | — | CN | disclosed |
| CN-105566214-A | Preparation process of 3-[2-(3-chlorphenyl)ethyl]-2-pyridinecarboxylic acid | SHANGHAI INST PHARMACEUTICAL IND | 2016-05-11 | — | — | CN | disclosed |
| US-20090005567-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO (5,6)-CYCLOHEPTA-(1,2B) -PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZACH SYSTEM S.P.A. (IT) | 2009-01-01 | — | — | US | disclosed |
| US-20090005567-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO (5,6)-CYCLOHEPTA-(1,2B) -PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | ZACH SYSTEM S.P.A. (IT) | 2009-01-01 | — | — | US | disclosed |
| US-20030144314-A1 | PROCESS OF SYNTHESIS OF A TRICYCLIC KETONE INTERMEDIATE | SCHERING CORPORATION | 2003-07-31 | — | — | US | disclosed |
| WO-2003040140-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO(5,6)-CYCLOHEPTA-(1,2B)-PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLI C ACID ETHYL ESTER (LORATADINE) | ZAMBON GROUP S.P.A. (IT) | 2003-05-15 | — | — | WO | disclosed |
| WO-2003016281-A1 | A PROCESS OF SYNTHESIS OF A TRICYCLIC KETONE INTERMEDIATE | SCHERING CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |
| EP-1098882-A1 | A PROCESS FOR PREPARING BENZOCYCLOHEPTAPYRIDIN-11-ONES | RUSSINSKY LIMITED (IE) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000005215-A1 | A PROCESS FOR PREPARING BENZOCYCLOHEPTAPYRIDIN-11-ONES | RUSSINSKY LIMITED (IE) | 2000-02-03 | — | — | WO | disclosed |
| US-4873335-A | 3-phenethyl-2-benzene-amides or aza-derivatives thereof | SCHERING CORPORATION (US) | 1989-10-10 | — | — | US | disclosed |
| US-4731447-A | Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof | SCHERING CORPORATION (US) | 1988-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005567-A1 | PROCESS FOR THE PREPARATION OF 4-(8-CHLORO-5,6-DIHYDRO-11H-BENZO (5,6)-CYCLOHEPTA-(1,2B) -PYRIDIN-11-YLIDENE)-1-PIPERIDINECARBOXYLIC ACID ETHYL ESTER (LORATADINE) | HRH4, HRH2, GRIN3A | BACE1 3426/4885KDM4E 230/4885MAPT 3169/4885 |
| US-20050171352-A1 | Process for the preparation of 4-(8-chloro-5 6-dihydro-11h-benzo-(5 6)-cyclohepta-(1 2b)-pyridin-11-ylidene-1-piperidiniecarboxylic acid ethyl ester (loratadine) | HRH4, HRH2, HRH1 | BACE1 3974/4885KDM4E 230/4885MAPT 3263/4885 |
| US-20030144314-A1 | PROCESS OF SYNTHESIS OF A TRICYCLIC KETONE INTERMEDIATE | CYP4F11, CYP2F1, KYAT1 | BACE1 1504/4885KDM4E 872/4885MAPT 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.