Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | ME2 | P23368 | 1/20 | 0.57 |
| ▸ | ME1 | P48163 | 1/20 | 0.57 |
| ▸ | ME3 | Q16798 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14372219 | 0.90 | CYP1A2 (0.63) | HRH3NPC1RAB9AMAPTCA12 | |
| SCHEMBL4559582 | 0.84 | PANK3 (0.60) | NPC1RAB9AMAPTCA12CA2 | |
| SCHEMBL4560480 | 0.83 | GAA (0.65) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL26758591 | 0.81 | MAPT (0.84) | NPC1RAB9AMAPTCA12CA2 | |
| SCHEMBL13912 | 0.81 | KMT2A (0.75) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL28106923 | 0.81 | RAB9A (0.70) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL1430921 | 0.80 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL14365697 | 0.78 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6632925 | 0.78 | CA12 (0.89) | NPC1RAB9AMAPTCA12CA2 | |
| SCHEMBL13234944 | 0.78 | CA12 (0.89) | MAPTCA12CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | GALAPAGOS NV (BE) | 2009-05-28 | — | — | US | disclosed |
| WO-2008055959-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | PDE4A, PDE7B, PDE4B | HRH3 4094/4885NPC1 3876/4885RAB9A 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.