Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 10/20 | 0.60 |
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23566353 | 0.87 | SCD (0.63) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL8125579 | 0.85 | SCD (0.89) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL4477605 | 0.84 | RAB9A (0.61) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL18884204 | 0.84 | SCD (0.60) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL11410245 | 0.84 | SCD (0.60) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL21858360 | 0.83 | RAB9A (0.61) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL11195754 | 0.81 | NPC1 (0.70) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL3794442 | 0.81 | NPC1 (0.61) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL9891923 | 0.80 | KDM4E (0.59) | SCDRAB9ANPC1GAASMN1; SMN2 | |
| SCHEMBL13490131 | 0.80 | MAPT (0.59) | SCDRAB9ANPC1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |