SCHEMBL4477605

SCHEMBL4477605

CC(=O)Nc1nc2ccccc2o1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 9/20 0.61
NPC1 O15118 8/20 0.61
SMN1; SMN2 Q16637 4/20 0.61
TP53 P04637 1/20 0.61
SCD O00767 1/20 0.60
CSNK1D P48730 1/20 0.56
GAA P10253 3/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
ALDH1A1 P00352 5/20 0.53
PKM P14618 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
KDM4E B2RXH2 4/20 0.53
LMNA P02545 1/20 0.53
NR4A2 P43354 1/20 0.53
HSP90AA1 P07900 1/20 0.51
MAPT P10636 3/20 0.50
TDP1 Q9NUW8 1/20 0.50
PIK3CA P42336 1/20 0.49
GLA P06280 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23566353 0.86 SCD (0.63) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL13522335 0.85 RAB9A (0.53) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL4558136 0.84 SCD (0.66) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL11195754 0.83 NPC1 (0.70) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL11410245 0.83 SCD (0.60) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL18884204 0.83 SCD (0.60) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL9891923 0.82 KDM4E (0.59) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL14029194 0.81 NPC1 (0.58) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL8125579 0.80 SCD (0.89) RAB9ANPC1SMN1; SMN2TP53SCD
SCHEMBL15450923 0.79 PIK3CA (0.51) RAB9ANPC1SMN1; SMN2TP53MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0157146-B1 SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1989-09-27 EP claimed
EP-0126433-B1 SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1989-03-22 EP claimed
US-4698297-A INCLUDING A CHEMICALLY STABLE COMPOUND ABLE TO RELEASE A USEFUL CONTROLLABLE GROUP HAVING GOOD DIFFUSION; SHARPNESS FUJI PHOTO FILM CO., LTD. (JP) 1987-10-06 US claimed
US-4618571-A STORAGE-STABLE COUPLERS; CONTROLLED-RELEASABLE COMPOUNDS FUJI PHOTO FILM CO., LTD. (JP) 1986-10-21 US claimed
US-4565777-A Silver halide color photographic light-sensitive materials FUJI PHOTO FILM CO., LTD. (JP) 1986-01-21 US claimed
EP-0157146-A2 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1985-10-09 EP claimed
US-4526861-A Heterocyclic ring contains imide or sulfonamide group FUJI PHOTO FILM CO., LTD. (JP) 1985-07-02 US claimed
US-4511649-A Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1985-04-16 US claimed
EP-0126433-A2 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1984-11-28 EP claimed
US-20170355705-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-12-14 US disclosed
US-9284278-B2 Electroluminescent metal complex BASF SE (DE) 2016-03-15 US disclosed
CN-103911038-A Ink composition used for roller printing DONGWOO FINE CHEM CO LTD 2014-07-09 CN disclosed
US-8629157-B2 Pyrrolidine compounds which modulate the CB2 receptor BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-01-14 US disclosed
US-7595334-B2 N-(on SO2 ) (2-hydroxy-3-substituted aminopropyl)-substituted; inhibiting retroviral replication TIBOTEC PHARMACEUTICALS LTD. (IE) 2009-09-29 US disclosed
US-4500634-A MIXTURE OF COUPLER CAPABLE OF RELEASING A DIFFUSIBLE DEVELOPMENT INHIBITOR AND COUPLER LATEX FUJI PHOTO FILM CO., LTD. (JP) 1985-02-19 US disclosed
EP-0126433-A2 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1984-11-28 EP disclosed
EP-0107112-A2 Silver halide color photographic light-sensitive materials FUJI PHOTO FILM CO., LTD. (JP) 1984-05-02 EP disclosed
EP-0101621-A2 Silver halide color photographic material FUJI PHOTO FILM CO., LTD. (JP) 1984-02-29 EP disclosed
US-4146712-A PROCESS FOR THE MANUFACTURE OF COUMARIN DYES CIBA-GEIGY CORPORATION (US) 1979-03-27 US disclosed
US-4072525-A COLOR PHOTOGRAPHY FUJI PHOTO FILM CO., LTD. (JA) 1978-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355705-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS SIRT1, SIRT3, SIRT2 RAB9A 1168/4885NPC1 3073/4885SMN1; SMN2 2016/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.