Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8520592 | 0.79 | CHRM1 (0.38) | CHRM1ALDH1A1 | |
| SCHEMBL2141410 | 0.70 | — | — | |
| SCHEMBL4558468 | 0.68 | KDM1A (0.48) | NPSR1KDM4ECHRM1CHRM2CHRM4 | |
| SCHEMBL8519318 | 0.65 | CHRM1 (0.48) | KDM4ECHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL13992792 | 0.64 | ALDH1A1 (0.38) | KDM4ECHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL28622348 | 0.64 | — | — | |
| SCHEMBL753752 | 0.63 | HCAR2 (0.37) | CHRM1TP53NPC1ALDH1A1HCAR2 | |
| SCHEMBL13992800 | 0.63 | SLC6A4 (0.38) | KDM4ECHRM1TP53NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL22616242 | 0.62 | — | — | |
| SCHEMBL28668359 | 0.62 | CHRM1 (0.32) | CHRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017454-A1 | NEW THERAPEUTIC COMBINATION OF A GSK3 INHIBITOR AND AN A7-NICOTINIC AGONIST 960 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017454-A1 | NEW THERAPEUTIC COMBINATION OF A GSK3 INHIBITOR AND AN A7-NICOTINIC AGONIST 960 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |