Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017941 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2HIF1AEPAS1HSD17B10KMT2A | |
| SCHEMBL4557856 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2HSD17B10KMT2ATDP1PKM | |
| SCHEMBL4014562 | 0.74 | HIF1A (0.46) | HIF1AEPAS1 | |
| SCHEMBL359688 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2HSD17B10KMT2AMEN1GAA | |
| SCHEMBL4564379 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2HIF1AEPAS1HSD17B10MAPT | |
| SCHEMBL8154810 | 0.71 | HIF1A (0.51) | HIF1AEPAS1 | |
| SCHEMBL8589360 | 0.71 | HIF1A (0.51) | SMN1; SMN2HIF1AEPAS1HSD17B10KMT2A | |
| SCHEMBL1803272 | 0.69 | CYP4Z1 (0.56) | SMN1; SMN2HSD17B10KMT2ACYP4Z1MEN1 | |
| SCHEMBL12571386 | 0.68 | HIF1A (0.60) | HIF1AEPAS1MAPT | |
| SCHEMBL29744098 | 0.68 | KDM4E (0.53) | SMN1; SMN2HSD17B10KMT2APKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015180-A2 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |