Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836345 | 0.98 | BCHE (0.45) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL16191233 | 0.88 | SMN1; SMN2 (0.43) | MAOBBCHEOPRM1OPRD1OPRK1 | |
| SCHEMBL10534699 | 0.85 | MAOB (0.41) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL10697228 | 0.83 | MAOB (0.55) | MAOAMAOBBCHECYP1A2 | |
| SCHEMBL16191317 | 0.81 | NPC1 (0.54) | OPRM1OPRD1OPRK1 | |
| SCHEMBL16191351 | 0.80 | OPRM1 (0.40) | MAOAMAOBOPRM1OPRD1OPRK1 | |
| SCHEMBL613243 | 0.79 | SIGMAR1 (0.43) | MAOAMAOBBCHEOPRM1OPRD1 | |
| SCHEMBL10235917 | 0.79 | KCNH2 (0.50) | — | |
| SCHEMBL20204743 | 0.79 | OPRM1 (0.42) | MAOAMAOBOPRM1OPRD1OPRK1 | |
| SCHEMBL612124 | 0.78 | SIGMAR1 (0.46) | MAOABCHEOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |