Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586537 | 0.94 | PDE5A (0.80) | PDE5A | |
| SCHEMBL3576653 | 0.94 | PDE5A (0.80) | PDE5A | |
| SCHEMBL3586544 | 0.94 | PDE5A (0.80) | PDE5A | |
| SCHEMBL3579697 | 0.92 | PDE5A (0.76) | PDE5A | |
| SCHEMBL3576135 | 0.91 | PDE5A (0.89) | PDE5APDE6C | |
| SCHEMBL3583417 | 0.91 | PDE5A (0.89) | PDE5APDE6C | |
| SCHEMBL3585795 | 0.91 | PDE5A (0.89) | PDE5APDE6C | |
| SCHEMBL3576139 | 0.91 | PDE5A (0.89) | PDE5APDE6C | |
| SCHEMBL2403760 | 0.90 | PDE5A (0.77) | PDE5A | |
| Gisadenafil SCHEMBL120995 | 0.87 | PDE5A (1.00) | PDE5APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576099-B2 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | RENOVIS, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-20060194801-A1 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | EVOTEC AG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194801-A1 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | TRPV1, TRPA1, TRPV2 | PDE5A 1859/4885PDE6C 1838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.