Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 6/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | TYK2 | P29597 | 5/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562626 | 0.89 | ALDH1A1 (0.45) | KDM4EALDH1A1MAPK1JAK1JAK2 | |
| SCHEMBL4561292 | 0.88 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPK1JAK1JAK2 | |
| SCHEMBL4561201 | 0.88 | KDM4E (0.43) | KDM4EALDH1A1MAPK1JAK1JAK2 | |
| SCHEMBL4561894 | 0.88 | JAK3 (0.46) | KDM4EALDH1A1MAPK1JAK1JAK2 | |
| SCHEMBL4562265 | 0.87 | KDM4E (0.43) | KDM4EALDH1A1MAPK1JAK1JAK2 | |
| SCHEMBL4562639 | 0.86 | JAK1 (0.53) | KDM4EALDH1A1MAPK1JAK1JAK2 | |
| SCHEMBL4562570 | 0.86 | IGF1R (0.48) | GRIN2BKDM4EALDH1A1MAPK1JAK1 | |
| SCHEMBL5021994 | 0.85 | KDM1A (0.45) | GRIN2BKDM4EALDH1A1MAPK1JAK1 | |
| SCHEMBL4560124 | 0.85 | AXL (0.45) | GRIN2BKDM4EALDH1A1MAPK1JAK1 | |
| SCHEMBL5021907 | 0.84 | AXL (0.46) | JAK1JAK2TYK2KDM1AJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |