Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 11/20 | 0.42 |
| ▸ | JAK2 | O60674 | 10/20 | 0.42 |
| ▸ | JAK1 | P23458 | 9/20 | 0.42 |
| ▸ | TYK2 | P29597 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562626 | 0.91 | ALDH1A1 (0.45) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4561292 | 0.90 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4561201 | 0.89 | KDM4E (0.43) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4561894 | 0.89 | JAK3 (0.46) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4562570 | 0.87 | IGF1R (0.48) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4562639 | 0.87 | JAK1 (0.53) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL5021994 | 0.87 | KDM1A (0.45) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4559533 | 0.87 | GRIN2B (0.43) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4560124 | 0.86 | AXL (0.45) | KDM4EALDH1A1MAPK1JAK3JAK2 | |
| SCHEMBL4560682 | 0.84 | FGFR1 (0.54) | KDM4EALDH1A1MAPK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638018-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | Cellzome Limited (GB) | 2013-09-18 | — | — | EP | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | claimed |
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |