Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 11/20 | 0.68 |
| ▸ | HTR7 | P34969 | 5/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | IDH1 | O75874 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559827 | 1.00 | PLK1 (0.68) | PLK1HTR7ADRA1DHTR2CADRA1A | |
| SCHEMBL1928042 | 0.81 | PLK1 (1.00) | PLK1CSF1R | |
| SCHEMBL1928039 | 0.81 | PLK1 (1.00) | PLK1CSF1R | |
| SCHEMBL10219318 | 0.71 | HTR7 (0.53) | PLK1HTR7ADRA1DHTR2CADRA1A | |
| SCHEMBL7014490 | 0.70 | HTR7 (0.59) | PLK1HTR7ADRA1DHTR2CADRA1A | |
| SCHEMBL14629467 | 0.69 | HTR7 (0.57) | PLK1HTR7ADRA1DHTR2CADRA1A | |
| SCHEMBL10271508 | 0.68 | HTR7 (0.56) | PLK1HTR7ADRA1DHTR2CADRA1A | |
| SCHEMBL17076676 | 0.68 | MAPK14 (0.56) | PLK1HTR7ADRA1DHTR2CADRA1A | |
| SCHEMBL28120957 | 0.68 | HTR7 (0.57) | PLK1HTR7ADRA1DHTR2CADRA1A | |
| SCHEMBL1600112 | 0.68 | HTR7 (0.56) | PLK1HTR7ADRA1DHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021316-A1 | INHIBITORS OF POLO-LIKE KINASES | Abbott Laboratories (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007140233-A1 | INHIBITORS OF POLO-LIKE KINASES | ABBOTT LABORATORIES (US) | 2007-12-06 | — | — | WO | disclosed |